Peripheral basophil reactivity, CD203c expression by Cryj1 stimulation, is useful for diagnosing seasonal allergic rhinitis by Japanese cedar pollen
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چکیده
منابع مشابه
Peripheral basophil reactivity, CD203c expression by Cryj1 stimulation, is useful for diagnosing seasonal allergic rhinitis by Japanese cedar pollen
Measuring specific IgE can yield direct, accurate, and objective data. Nevertheless, clinical symptoms of allergy are often inconsistent with these data. Recently, the expression of CD203c, a surface marker of basophils, has been reported as capable of distinguishing allergic patients. This study compared specific IgE in serum and skin tests against antigen to assess CD203c as a biomarker corre...
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および鼻閉を主症状とする典型的な I型アレルギー疾 患である.くしゃみおよび鼻汁分泌の亢進は,抗ヒス タミン薬により抑制される.一方,患者にとって最も 苦痛を強いられる鼻閉にはグルココルチコイドが繁用 されるが,周知のごとくグルココルチコイドは優れた 効果を発揮するが副作用も強く,これに代わる鼻閉の 治療薬が望まれている.実験動物を用いたヒトの病態 を反映した良好なモデルは,新規治療薬の開発に極め て重要な位置にあることは論をまたない.そこで,我々 はモルモットを用いてスギ花粉抽出エキスで経鼻的に 感作し,以後スギ花粉の反復吸入を行うことにより, ヒトの病態に類似した症状を呈するアレルギー性鼻炎 モデルの開発を企図した.本法により,抗原惹起後に 明らかなくしゃみおよび二相性の鼻閉が認められ,く しゃみの発現は周知のごとく抗ヒスタミン薬で強力に 抑制された.一方,遅発性の鼻閉は,システ...
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A further confounding feature is the presence of persistent allergic rhinitis (PAR). The symptoms for this are different, in that the nose is Dermot Ryan, honorary clinical research fellow, University of Edinburgh; chair, Primary Care Interest Group, European Academy of Allergy and Clinical Immunology Allergic rhinitis (AR) is a common disorder which has a major impact on the lives of sufferers...
متن کاملAllergen-specific basophil reactivity exhibits daily variations in seasonal allergic rhinitis
It remains poorly understood how symptoms in allergic rhinitis are most severe during overnight or early in the morning. The circadian clock consisting of a network of several 'clock genes' including Clock drives daily rhythms in physiology. This study showed that allergen-induced surface CD203c expression on basophils in seasonal allergic rhinitis caused by Japanese cedar pollen exhibited a ti...
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ژورنال
عنوان ژورنال: Immunity, Inflammation and Disease
سال: 2015
ISSN: 2050-4527,2050-4527
DOI: 10.1002/iid3.69